UpToDate is an evidence-based clinical decision support resource at the point of care. UpToDate authors and editors synthesize the available clinical evidence and best clinical practices to help you provide high-quality care to your patients and high standards of research. They follow a systematic and transparent editorial policy for identifying, reviewing and synthesizing clinical evidence as it applies to a clinical question. To create and update the clinical topics in UpToDate, our editorial staff performs comprehensive reviews of the medical literature and considers the quality of the study, the hierarchy of evidence, and its clinical relevance.